ArticleScience translational medicine2025
Burst-patterned stimulation restores colonic motility in preclinical models.
Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications.Frontiers in neuroscience · 2026Review
- Optimizing sacral nerve stimulation to relieve chronic constipation.Nature reviews. Gastroenterology & hepatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Disrupted communication along the brain-gut axis contributes to impaired visceral function and debilitating symptoms. Colonic dysmotility, in particular, remains poorly managed by conventional pharmaceuticals. The objectives of our study were to restore colonic motility by electrical stimulation of the sacral nerves, optimize the stimulation pattern to relieve constipation, and elucidate the mechanisms of motor patterns evoked by stimulation. Through a combination of computational, ex vivo, and in vivo preclinical models, we engineered temporal patterns of sacral nerve stimulation to evoke maximally propulsive, prokinetic motility. We validated the optimized pattern of stimulation by measuring defecatory behavior in a loperamide model of constipation in rats. Compared with sham stimulation and the continuous pattern of stimulation conventionally used in the clinic, burst-patterned sacral nerve stimulation significantly increased fecal output to baseline and relieved constipation in awake, behaving rats. Further, we systematically varied stimulation frequency, stimulation duration, and interburst interval and determined the minimum effective parameters to maximize anorectal contractions. We demonstrated that a precise temporal pattern of sacral nerve stimulation relieves constipation in rats, establishing preclinical evidence and the foundational principles for translation to future pilot clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.