ArticleScience advances2025
Neural correlates of phosphene perception in blind individuals: A step toward a bidirectional cortical visual prosthesis.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02983370 (Pilot Study for the Development of a Cortical Visual Neuroprosthesis for the Blind Based on Intracortical Microelectrodes), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study for the Development of a Cortical Visual Neuroprosthesis for the Blind Based on Intracortical Microelectrodes
Who cites it
6 citing papers in PubMed.
- Long-term safety and efficacy of intracortical microstimulation in humans.Science translational medicine · 2026Trial
- Seeing anew: Mechanisms, outcomes, and challenges in adapting to restored sight via visual prostheses.Progress in retinal and eye research · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Article
- Fuzzing the brain: automated stress testing for the safety of ML-driven neurostimulation.Journal of neural engineering · 2026Article
- Review of brain-computer interface technology in ophthalmology: Current status, challenges and future directions.Advances in ophthalmology practice and researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blindness is one of the most impactful disabilities in human lives. Cortical prostheses could one day restore functional vision in some blind subjects, but their success will depend on integrating advanced technologies to realize the therapeutic benefits they promise. Most previous studies in humans used electrodes only for stimulation, which has made it challenging to precisely control the appearance of individual phosphenes. Herein, we implanted an intracortical microelectrode array of 100 electrodes in the visual cortex of two blind volunteers. We recorded the neural activity around the electrodes while performing electrical stimulation to induce visual perceptions. Besides showing how stimulation parameters influence perceptual thresholds, perceived brightness, and the minimum interval required to distinguish separate stimuli, our results indicate that subjective visual experience can be accurately predicted from the recorded neural activity. These results highlight the potential for using the neural activity of neighboring electrodes to accurately infer and control visual perceptions in cortical visual prostheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.