Evidence map›Paper›PMID 41191689›Full record

ReviewRevista da Sociedade Brasileira de Medicina Tropical2025

Tuberculosis and the Research Workforce Renewal Crisis in Brazil: How Can We Prevent a Future Without New Researchers?

Beatriz Barreto-Duarte, Klauss Villalva-Serra, Ricardo Alexandre Arcêncio, Julio Croda, Ethel Leonor Noia Maciel, Afrânio Lineu Kritski, Bruno Bezerril Andrade

Abstract readReview
In one paragraph

Review in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beatriz Barreto-DuarteLaboratório de Pesquisa Clínica e Translacional, Fundação Oswaldo Cruz, Salvador, BA, Brasil.ORCID http://orcid.org/0000-0002-9901-8328
Klauss Villalva-SerraLaboratório de Pesquisa Clínica e Translacional, Fundação Oswaldo Cruz, Salvador, BA, Brasil.ORCID http://orcid.org/0000-0001-9499-7929
Ricardo Alexandre ArcêncioRede Brasileira de Pesquisas em Tuberculose (REDE-TB), Rio de Janeiro, RJ, Brasil .ORCID http://orcid.org/0000-0003-4792-8714
Julio CrodaRede Brasileira de Pesquisas em Tuberculose (REDE-TB), Rio de Janeiro, RJ, Brasil .ORCID http://orcid.org/0000-0002-6665-6825
Ethel Leonor Noia MacielRede Brasileira de Pesquisas em Tuberculose (REDE-TB), Rio de Janeiro, RJ, Brasil .ORCID http://orcid.org/0000-0003-4826-3355
Afrânio Lineu KritskiRede Brasileira de Pesquisas em Tuberculose (REDE-TB), Rio de Janeiro, RJ, Brasil .ORCID http://orcid.org/0000-0002-5900-6007
Bruno Bezerril AndradeLaboratório de Pesquisa Clínica e Translacional, Fundação Oswaldo Cruz, Salvador, BA, Brasil.ORCID http://orcid.org/0000-0001-6833-3811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is among the oldest and deadliest infectious diseases, particularly when associated with human immunodeficiency virus (HIV) and antimicrobial resistance. Despite the progress in prevention, diagnosis, and treatment, global elimination remains elusive and is driven largely by socioeconomic inequalities and systemic challenges. Although scientific research is a cornerstone of the WHO End TB Strategy, it has been chronically underfunded and undervalued in Brazil's health agenda. One critical consequence is the weakening of pipelines for future TB research. Funding shortages, lack of incentives, and the shifting attention toward s other emerging diseases have made it increasingly difficult to recruit and retain scientists in the field of TB. This opinion paper aimed to explore the historical role of Brazilian science in advancing TB control while addressing the emerging crisis of renewing the country's TB scientific workforce. We conducted a narrative synthesis of the available literature, reviewing impactful peer-reviewed articles produced by Brazilian scientists in the field of TB science, alongside official documents from the Brazilian Ministry of Health. This was complemented by a bibliometric analysis of the output of TB-related PhD theses (2016-2024) and PubMed-indexed publications (2001-2024) from Brazilian institutions. Finally, we discuss the systemic barriers affecting early career researchers and outline strategies for revitalizing interest and sustaining scientific progress. These include targeted TB research funds through public-private partnerships, structured mentorship programs, and competitive early career fellowships. Such interventions are essential for reversing the current decline in TB research engagement and ensuring that Brazil continues to contribute to global TB elimination efforts while preserving its scientific legacy.

Indexed as

Biomedical ResearchResearch PersonnelTuberculosisBrazilHumans

Identifiers

PMID41191689
PMCPMC12585154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.