Evidence map›Paper›PMID 41191588›Full record

ArticlePLOS digital health2025

Creating a general-purpose generative model for healthcare data based on multiple clinical studies.

Hiroshi Maruyama, Kotatsu Bito, Yuki Saito, Masanobu Hibi, Shun Katada, Aya Kawakami, Kenta Oono, Nontawat Charoenphakdee, Zhengyan Gao, Hideyoshi Igata and 7 more

Abstract read
In one paragraph

Article in PLOS digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hiroshi MaruyamaKao Corporation, Chuo-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0001-6597-0436
Kotatsu BitoDigital Business Creation, Kao Corporation, Chuo-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0002-3197-7880
Yuki SaitoDigital Business Creation, Kao Corporation, Chuo-ku, Tokyo, Japan.
Masanobu HibiHuman Health Care Product Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan.
Shun KatadaHuman Health Care Product Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan.
Aya KawakamiDigital Business Creation, Kao Corporation, Chuo-ku, Tokyo, Japan.
Kenta OonoPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Nontawat CharoenphakdeePreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Zhengyan GaoPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Hideyoshi IgataPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Masashi YoshikawaPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Yoshiaki OtaPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Hiroki OkuiPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Kei AkitaPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Shoichiro YamaguchiPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Yohei SugawaraPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.
Shin-Ichi MaedaPreferred Networks Inc., Chiyoda-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data for healthcare applications are typically customized for specific purposes but are often difficult to access due to high costs and privacy concerns. Rather than prepare separate datasets for individual applications, we propose a novel approach: building a general-purpose generative model applicable to virtually any type of healthcare application. This generative model encompasses a broad range of human attributes, including age, sex, anthropometric measurements, blood components, physical performance metrics, and numerous healthcare-related questionnaire responses. To achieve this goal, we integrated the results of multiple clinical studies into a unified training dataset and developed a generative model to replicate its characteristics. The model can estimate missing attribute values from known attribute values and generate synthetic datasets for various applications. Our analysis confirmed that the model captures key statistical properties of the training dataset, including univariate distributions and bivariate relationships. We demonstrate the model's practical utility through multiple real-world applications, illustrating its potential impact on predictive, preventive, and personalized medicine.

Identifiers

PMID41191588
PMCPMC12588491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.