ArticleACS sensors2025
Fuel-Free Rolosense: Viral Sensing Using Diffusional Particle Tracking.
Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
High-sensitivity viral diagnostics typically use PCR to detect and amplify viral nucleic acids which requires fluorescence reporters, enzymatic amplification, specialized equipment and can be time-consuming. In this work, we describe fuel-free (FF) Rolosense, a diagnostic approach that leverages mechanical force sensing as a fundamental transduction mechanism. We use the Brownian motion of aptamer-coated microparticles on an aptamer-modified surface for viral detection. The microparticles function as both the sensing and transduction elements, reporting specific molecular interactions where the presence of viral particles stalls their motion by cross-linking them to the surface. FF-Rolosense harnesses biased motion and thermal fluctuations to achieve rapid, sensitive, and specific detection of intact virions─the active agents of infection. This approach represents a fundamental shift from conventional diagnostic methods and demonstrates a limit of detection as low as 10
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