ArticleEndocrinology, diabetes & metabolism case reports2025
A case of severe neonatal hypercalcaemia secondary to neonatal thyrotoxicosis.
Article in Endocrinology, diabetes & metabolism case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Summary: A 3-week-old male infant presented with poor feeding, lethargy, and weight loss. Clinical examination revealed mildly elevated tachycardia, but otherwise there were no clinical signs evident. Initial investigations revealed hypercalcaemia, which was subsequently found to be secondary to transient thyrotoxicosis. Hypercalcaemia was managed with hyperhydration along with a low-calcium infant formula, and thyrotoxicosis responded to treatment with carbimazole. Serum calcium levels gradually normalised with resolution of the neonatal thyrotoxicosis and weight gain. Subsequently, all treatment was gradually weaned over 4 months. The infant remained clinically well on follow-up with normal growth, and his laboratory investigations normalised. Learning points: Hypercalcaemia is a recognised complication of thyrotoxicosis. Evidence in the paediatric population is limited, and this is the first reported case of hypercalcaemia noted to occur secondary to neonatal thyrotoxicosis. Signs and symptoms of both hypercalcaemia and thyrotoxicosis can be non-specific and subtle. An awareness of the condition and a high index of suspicion are required in order to make the diagnosis. While asymptomatic neonatal hypercalcaemia may be transient and self-limiting, symptomatic patients require treatment with hyperhydration. Serum calcium levels in combination with parathyroid hormone, vitamin D, and urine calcium-creatinine ratios can help narrow the differential diagnoses, but it is important that the underlying cause is carefully investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.