ArticleACS applied materials & interfaces2025
Thermo-Magnetic Induction of Pro-Inflammatory Microglia: A Lipid-Based Nanovector Strategy for Glioblastoma Immunotherapy.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Spatiotemporal cancer controlNanomedicine (London, England) · 2026Review
- Dual-Function Lipid-Based Nanovector Strategy for Glioblastoma Immunotherapy: STING Activation and M1 Microglia Polarization.Drug development research · 2026Review
- Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Magnetic hyperthermia as an intracellular immunomodulatory technology: From heat transduction to tumor immune reprogramming.Theranostics · 2026Review
- HMC3 revealed: how much do these "Microglia" really tell us?Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia, the main immune cells in the central nervous system (CNS), maintain physiological homeostasis and react to pathological changes. Besides their neuroprotective function, they play a crucial role in brain tumor microenvironments such as glioblastoma (GBM), by composing up 40% of the tumor mass. Glioma-associated microglia exhibit a dynamic activation state characterized mainly by an immunosuppressive (M2-like) response, with a lesser contribution of pro-inflammatory (M1-like) response. Modulating microglial into M1-like phenotype offers antitumor response and a promising immunotherapy strategy against GBM. Nanoparticles can induce microglial polarization, also modulating pro-inflammatory responses for tumor suppression. Magnetically responsive nanoparticles are promising nanotransducers due to their remote-control capabilities via external magnetic fields, enabling precise therapeutic interventions. This study proposes a novel strategy that exploits lipid-based magnetic nanovectors (LMNVs) composed of a lipid matrix doped with iron oxide nanoparticles to induce M1-like microglial response through magneto-thermal conversion. Results demonstrated that LMNVs exhibit excellent biocompatibility and efficient internalization within human microglia (HMC3 cells). Upon alternating magnetic field (AMF) stimulation, LMNVs triggered a sustained increase in intracellular Ca
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Registered trials
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