Evidence map›Paper›PMID 41191290›Full record

SynthesisInternal and emergency medicine2026

Comparison of non-invasive strategies to drive fluid resuscitation in sepsis or septic shock: a meta-analysis of RCTs.

Mara Graziani, Laura Gasperini, Claudia Gasperini, Giorgio Maraziti, Gennaro De Pascale, Cecilia Becattini

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mara GrazianiInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy. maragraziani11@gmail.com.ORCID http://orcid.org/0000-0002-9665-912X
Laura GasperiniInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Claudia GasperiniInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Giorgio MarazitiInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Gennaro De PascaleDepartment of Emergency Science, Anesthesiology, and Resuscitation, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Cecilia BecattiniInternal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early fluid resuscitation reduces mortality in patients with sepsis or septic shock, but excessive fluid administration may prolong hospitalization and increase complications. Several non-invasive strategies have been proposed to guide fluid resuscitation, yet their comparative efficacy remains uncertain. We systematically searched PubMed and EMBASE through June 2025 to identify randomized controlled trials evaluating non-invasive strategies to guide fluid resuscitation in adult patients with sepsis or septic shock. Pairwise and network meta-analyses were conducted to assess short-term mortality. Length of stay (LOS) in intensive care unit (ICU) was also analyzed. 20 RCTs (2.435 patients) were included. In pairwise meta-analyses, lactate clearance-guided resuscitation was associated with reduced short-term mortality compared to ScvO₂ (RR 0.81, 95% CI 0.65-1.00; I

Indexed as

Fluid TherapyResuscitationSepsisShock, SepticHumansLength of StayRandomized Controlled Trials as TopicCapillary refill timeEchocardiographyFluid resuscitationLactate clearancePassive leg-raisingSepsisSeptic shockStroke volumeUltrasoundUsual care

Identifiers

PMID41191290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.