Observational studyInternational urology and nephrology2026
The diagnostic value of native and early post-contrast CT attenuation in differentiating benign from potentially malignant adrenal lesions.
Observational study in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdrenal gland lesions are increasingly detected as incidental findings during standard abdominal CT examinations. The aim of this study was to evaluate the diagnostic utility of native and early post-contrast (1-min) CT attenuation values, as well as lesion size, in differentiating benign from potentially malignant adrenal lesions, and to determine optimal cut-off values for these parameters in a routine clinical setting.
methodsAn observational, historical cohort study included 50 patients who underwent adrenalectomy between 2012 and 2024, with available preoperative CT imaging. Based on histopathology, patients were classified as having benign or potentially malignant lesions. Native and 1-min postcontrast attenuation values in Hounsfield units, along with maximal lesion diameter, were obtained from preoperative scans. Demographic and clinical data were obtained from the institutional database. Statistical analysis included Mann-Whitney U and chi-squared tests, ROC curve analysis, and logistic regression.
resultsPotentially malignant lesions demonstrated significantly higher native attenuation, 1-min postcontrast attenuation, and larger size. ROC analysis identified optimal cut-offs of 15 HU (native), 59 HU (1-min postcontrast), and 4.2 cm (size). In univariate analysis, all three parameters were significantly associated with malignancy (p < 0.05). However, in multivariate analysis, only the 1-min postcontrast attenuation remained an independent predictor (p = 0.019).
conclusionNative and early postcontrast attenuation values differentiate benign from potentially malignant adrenal lesions, with the 1-min postcontrast phase showing the highest diagnostic accuracy. Multivariate analysis confirmed the 1-min postcontrast value as the only independent predictor of malignancy. These findings support the clinical utility of early-phase imaging in guiding management decisions and surgical planning.
Indexed as
Identifiers
41191268What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.