Wilms Tumor 1 Associated Protein (WTAP) Inhibits Inflammation Provoked by Mycobacterium tuberculosis in Microglial BV-2 Cells and Promotes Differentiation of Neural Stem/Progenitor Cells into Neurons by Elevating Expression of HMGN3 Protein Resulted from Modulation of m

Mingming Ma, Xingwu Zou, Jing Zhao, Zhaodong Li, Dongliang Guo, Xiaoyan Liu, Haibo Hua

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mingming MaDepartment of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China.

Xingwu ZouDepartment of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China.

Jing ZhaoDepartment of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China.

Zhaodong LiClinical Medical Laboratory Center, Hangzhou Red Cross Hospital, Hangzhou, China.

Dongliang GuoDepartment of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China.

Xiaoyan LiuDepartment of Neurology, Hangzhou Red Cross Hospital, Hangzhou, China.

Haibo HuaDepartment of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China. hhblhm@163.com.

Funding

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6 · The paper itself

Abstract

Tuberculous meningitis (TBM) is the most prevalent and severe manifestation of tuberculosis in CNS. The mechanisms of neurological injury caused by TBM are not well understood. Our study showed that overexpression of WTAP (Wilms tumor 1 associated protein) reduced inflammatory factors and Iba-1 expression induced in BV-2 by H37Rv. It also increased proliferation of neural stem/progenitor cells (NSPCs) and expression of the neuronal marker DCX in these cells. WTAP enhanced expression of high mobility group nucleosome-binding domain-containing protein 3 (HMGN3) by promoting m

Indexed as

HMGN ProteinsMicrogliaMycobacterium tuberculosisNeural Stem CellsTuberculosis, MeningealAdenosineAnimalsCell DifferentiationCell LineCell ProliferationDoublecortin ProteinInflammationMiceMicrofilament ProteinsNeuronsRNA, MessengerAdenosineDcx protein, mouseDoublecortin ProteinHMGN ProteinsMicrofilament ProteinsN-methyladenosineRNA, Messengerhigh mobility group nucleosome-binding domain-containing protein 3 (HMGN3)m6Amethylationtuberculous meningitisWilms tumor 1 associated protein (WTAP)

Identifiers

PMID41191238

DOI10.1093/stcltm/szad020

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