Evidence map›Paper›PMID 41191232›Full record

ReviewDiscover oncology2025

Role of exosomes in cancer: from diagnosis to therapy.

Mojgan Esparvarinha, Hamid Nickho, Mohsen Dashti, Majid Ebrahimi Warkiani, Mehdi Yousefi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mojgan EsparvarinhaDepartment of Immunology, School of Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0002-7814-5782
Hamid NickhoDepartment of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.ORCID http://orcid.org/0000-0002-0776-1123
Mohsen DashtiDepartment of Immunology, School of Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0003-4455-7858
Majid Ebrahimi WarkianiSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia.ORCID http://orcid.org/0000-0002-4184-1944
Mehdi YousefiDepartment of Immunology, School of Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. mehdi_yusefi@yahoo.com.ORCID http://orcid.org/0000-0003-0099-6728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small extracellular vesicles produced by most cell types. They carry specific markers and biomolecular cargo that reflect the characteristics of cancer cells. These vesicles contain oncoproteins, mutated DNA fragments, and cancer-specific RNA profiles, which can serve as biomarkers for tumor detection, disease progression, and treatment resistance analysis. As a non-invasive diagnostic tool, exosome biomarkers can be obtained from liquid biopsies, including blood, urine, and saliva samples. The cargo of exosomes, such as miRNAs and proteins, is often associated with patient prognosis, providing insights into tumor aggressiveness and survival rates, which helps in patient risk assessment. Due to their natural biocompatibility and minimal immune response, exosomes are promising drug delivery vehicles for anticancer treatments, including chemotherapeutic agents and RNA-based therapies. This review highlights the dual role of exosomes in cancer, focusing on their diagnostic and therapeutic potential.

Indexed as

CancerDendritic cell-derived exosomesDiagnostic biomarkersExosomesTherapeutic deliveryTumor-derived exosomes

Identifiers

PMID41191232
PMCPMC12589699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.