Evidence map›Paper›PMID 41191225›Full record

ArticleMolecular diversity2026

Discovery of potent DprE1-targeted antitubercular agents: synthesis and evaluation of PBTZ169/TBA7371-based derivatives.

Gunjal Amol Pandurang, S Anil Kumar, Amrita Thakur, Arun Bapurao Ingle, Milendra Turkar, Nitin Sonawane, Aniket Nandi, Kalicharan Sharma

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Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Gunjal Amol PandurangDepartment of Physical Sciences, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru Campus, Kasavanahalli, Carmelaram P.O., Bangalore, 560035, India.
S Anil KumarDepartment of Physical Sciences, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru Campus, Kasavanahalli, Carmelaram P.O., Bangalore, 560035, India. s_anilkumar@blr.amrita.edu.
Amrita ThakurDepartment of Physical Sciences, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru Campus, Kasavanahalli, Carmelaram P.O., Bangalore, 560035, India.
Arun Bapurao IngleAragen Life Sciences Private Limited, IDA, Mallapur, Hyderabad, Telangana, 500076, India.
Milendra TurkarSchool of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Bhopal, 462039, India.
Nitin SonawaneDepartment of Physical Sciences, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru Campus, Kasavanahalli, Carmelaram P.O., Bangalore, 560035, India.
Aniket NandiDepartment of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, Moga, Punjab, 142001, India.
Kalicharan SharmaDepartment of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, Moga, Punjab, 142001, India. sharmakcpt@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) has emerged as one of the most promising and validated drug targets for tuberculosis (TB), owing to its essential role in the biosynthesis of arabinogalactan, a crucial component of the Mycobacterium tuberculosis (Mtb) cell wall. In the present study, a series of sixteen novel derivatives (9a-9p) were synthesized based on the structural scaffolds of the clinical trial drugs PBTZ169 and TBA7371. The synthesized compounds were characterized by NMR and LC-MS techniques. All compounds were evaluated for their antitubercular activity against the Mtb H

Indexed as

Alcohol OxidoreductasesAntitubercular AgentsBacterial ProteinsDrug DiscoveryMycobacterium tuberculosisMicrobial Sensitivity TestsMolecular Docking SimulationSpiro CompoundsStructure-Activity RelationshipThiazines2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-oneAlcohol OxidoreductasesAntitubercular AgentsBacterial ProteinsDprE1 protein, Mycobacterium tuberculosisSpiro CompoundsThiazinesAntitubercular activityDprE1H 37 RvMABA assayMD simulation

Identifiers

PMID41191225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.