ArticleJournal of ophthalmic inflammation and infection2025
Uveitis-glaucoma-edema (UGE): a clinical triad in un-treated helminth-associated severe anterior segment inflammation.
Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo describe the clinical presentation, treatment response, and surgical management of anterior segment ocular helminthic infections.
methodsThis single-center case series included patients diagnosed with helminthic anterior uveitis based on the presence of a characteristic triad: anterior uveitis, elevated intraocular pressure (IOP), and corneal edema. All patients were initially treated with topical corticosteroids and antiglaucoma medications. Definitive treatment consisted of surgical extraction of the intraocular helminth after adequate control of inflammation and IOP.
resultsAll cases presented with Uveitis, raised IOP (Glaucoma), and corneal Edema (UGE) triad, which significantly impacted initial visualization and diagnosis. A non-touch surgical technique using viscoelastic-assisted dissection and capsulorhexis forceps was employed to extract the intraocular worms. Microscopic identification confirmed the organisms as Gnathostoma spinigerum, Wuchereria bancrofti, and Loa loa.
conclusionHelminthic infestation of the anterior segment, although rare, may present as a distinct clinical entity characterized by uveitis, secondary glaucoma, and corneal edema. Early recognition of this triad can raise clinical suspicion. Controlled inflammation and IOP normalization, followed by non-traumatic surgical extraction, are key to favorable outcomes.
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