ReviewDiscover oncology2025
The Reg gene family: roles in gastric and colorectal cancer progression and its potential for targeted therapy.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- HESTIA: scalable multimodal integration of histology and high-resolution spatial Transcriptomics for robust spatial domain identification.Briefings in bioinformatics · 2026Article
- Tamoxifen differentially modulates endometrial hyperplasia via wild-type and mutant p53 regulation of the ALKBH5-REG1A axis.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of human malignancies presents ongoing challenges in modern medicine, particularly given the high morbidity and mortality associated with gastrointestinal cancers. Despite advances in therapeutic strategies, tumor complexity and evolving resistance mechanisms persistently hinder effective clinical intervention. The Regenerating gene (Reg) family comprises small secreted proteins that have garnered considerable research interest in oncology owing to their multifunctional properties. These proteins play dual roles in maintaining gastrointestinal homeostasis while simultaneously driving key pathophysiological processes including tumor proliferation, invasion, metastasis, and therapeutic resistance, thereby emerging as promising targets for early diagnosis and precision therapies. This review systematically elucidates the expression dynamics and functional roles of Reg genes in gastrointestinal malignancies, analyzing their intricate crosstalk with cellular signaling pathways and focusing particularly on tumor microenvironment modulation mechanisms. The review aims to explore the role of the Reg gene family in gastrointestinal tumors and assess its potential as both diagnostic markers and therapeutic targets in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.