ArticlePlant cell reports2025
Overexpression of the glutathione synthase gene PsGSH2 enhances cadmium stress tolerance in transgenic Arabidopsis thaliana.
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- DELLA proteins enhance cadmium tolerance by coordinating redox protection and cadmium partitioning in Arabidopsis.Planta · 2026Article
- Enhancing Cryopreservation Efficiency inPlants (Basel, Switzerland) · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
key messageThis study first demonstrates that PsGSH2 enhances cadmium tolerance not only by boosting antioxidant defense but also by modulating metal transporter genes to reduce Cd accumulation in plants. Cadmium (Cd) stress poses a significant environmental issue. Potentilla sericea, characterized by strong resistance, is an excellent groundcover for pollution remediation. Glutathione synthetase is one of the key enzymes that promote the synthesis of the antioxidant glutathione (GSH). We cloned PsGSH2, which was up-regulated under Cd stress, and introduced it into Arabidopsis thaliana to validate the response of transgenic lines to Cd. The results showed that the expression level of PsGSH2 was significantly up-regulated (15.45-fold) in the roots of P. sericea under cadmium stress. Overexpression (OE) of PsGSH2 in A. thaliana significantly enhanced Cd tolerance. Compared to wild-type (WT) plants, OE lines exhibited a more than sevenfold increase in seed germination rate under Cd stress, with a significantly reduced biomass loss (< 40%). The transgenic lines showed enhanced photosynthetic performance, a reinforced antioxidant system (up to 1.9- and 2.2-fold higher than WT), and reduced oxidative damage (50-75% of WT). Crucially, they exhibited a 59.05% reduction in shoot Cd accumulation, supported by significantly lower bioconcentration factor and transport factor values (46.12% and 69.17%, respectively). Molecular analysis revealed upregulation (1.84- to 5.44-fold) of key genes related to Cd detoxification (AtGSH1, AtGSH2, AtIRT1, AtPCR1, AtPCR2, AtMT3). Therefore, this study provides valuable insights for developing Cd-tolerant plants through genetic engineering approaches, laying the foundation for further research on Cd resistance in P. sericea.
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