Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Active-fluidics versus gravity-fluidics in uncomplicated cataract surgery: using optical coherence tomography angiography to estimate early changes in macular and optic disc microcirculation.
Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
purposeTo compare, using optical coherence tomography angiography (OCTA), the earliest changes and damages to macular and optic disc microcirculation after active-fluidics system (AFS) and gravity-fluidics system (GFS) procedures in uncomplicated cataract surgery.
methodsWe included 42 eyes affected by uncomplicated cataracts and divided them into two groups: 21 eyes were randomly assigned to an AFS group and 21 eyes were randomly assigned to a GFS group. Expert examiners performed OCTA 30 ± 10 min before surgery (T0), 30 ± 8 min after surgery (T1), 24 ± 2 h after surgery (T2) and 7 days after surgery (T3).
resultsNo significant differences at T1 were detected between the groups. At T2, eyes in the GFS group exhibited a whole macula deep capillary plexus vessel density of 37.9 ± 5.8%, which was significantly lower than that of the eyes in the AFS group (42.2 ± 5.7%; p = 0.048). At T3, eyes in the GFS group exhibited a significantly higher retinal nerve fibre layer thickness in the nasal (p = 0.020) and inferior (p = 0.045) quadrant, and a significantly lower peripapillary vessel density in the inferior quadrant of the papilla (p = 0.036) compared with eyes in the AFS group.
conclusionThe AFS procedure appears to protect macular and optic disc microcirculation during phacoemulsification, and it may represent a more prudent approach, particularly in cases that require specific care to preserve residual peripapillary and macular vasculature (e.g., diabetic or glaucomatous eyes).
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