ArticleCardiology journal2026
Impact of cancer treatments on coronary plaque as assessed by integrated backscatter intravascular ultrasound.
Article in Cardiology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBoth cancer itself and cancer treatment [i.e., chemotherapy (CT) and radiotherapy (RT)] are associated with an increased risk of cardiovascular disease. The influence of cancer treatment on the coronary plaque profile was examined as assessed by integrated-backscatter intravascular ultrasound (IB-IVUS).
methodsThe patients analyzed were those who had undergone surgery, CT, or RT for cancer prior to undergoing percutaneous coronary intervention (PCI) using IVUS between 2010 and 2020. Grayscale and IB-IVUS analyses were performed for the culprit lesion of a coronary artery just before PCI. To determine the association of cancer treatment with outcomes [% plaque volume index (PVI) and % lipid plaque volume (LV)], we used regression models while adjusting for covariates.
resultsA total of 162 chronic coronary syndrome patients who underwent PCI using IVUS were included: 89 received either or both CT and RT ± surgery (CT/RT group), and 73 received surgery alone (surgery group). Compared to the surgery group, the CT/RT group had a high cancer stage, low creatinine and high % LV. By a univariate regression, % PVI was associated with cancer stage (β = -0.16, p = 0.02), RT (β = 0.4, p = 0.02) and HbA1c (β = 0.15, p = 0.01), and % LV was associated with CT/RT (β = 6.93, p = 0.01) and HbA1c (β = 3.65, p = 0.01). After adjustment for covariates, CT/RT was significantly associated with % LV (β = 6.77, p = 0.02), but not with % PVI (β = 0.25, p = 0.15).
conclusionsChemotherapy and RT were associated with the coronary plaque profile, but not with the coronary plaque volume. Chemotherapy and RT.
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