Evidence map›Paper›PMID 41190945›Full record

ArticleeLife2025

Evolving our understanding of trained immunity.

Eva Kaufmann, Yahya Sohrabi, Jorge Domínguez-Andrés, Boris Novakovic, Mihai G Netea, Jos W M van der Meer

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eva KaufmannMeakins-Christie Laboratories, RI-MUHC, and Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0001-7965-9200
Yahya SohrabiDepartment of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.ORCID https://orcid.org/0000-0001-5268-238X
Jorge Domínguez-AndrésDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0002-9091-1961
Boris NovakovicMurdoch Children's Research Institute and the Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Australia.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0003-2421-6052
Jos W M van der MeerDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new vaccines and therapeutics.

Indexed as

Immunity, InnateImmunologic MemoryAnimalsHumansTrained ImmunityVaccinesVaccinesepigenetic changesimmunologyimmunotherapyinfectious diseaseinflammationinnate immune cellsmicrobiologytrained immunity

Identifiers

PMID41190945
PMCPMC12588603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.