ArticleAdvanced materials (Deerfield Beach, Fla.)2026
A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed.
- Transmetallic biomimetic Hydrogel implants restore osteogenesis-angiogenesis coupling via Fe/Co ionic microenvironment remodeling for enhancing osteoporotic fracture healing.Bioactive materials · 2027Article
- A xenogeneic developmental matrix hydrogel with MnOBioactive materials · 2026Article
- Article
- Spatiotemporally programming the immune-osteogenic cascade with a dual-immunomodulatory scaffold for functional bone regeneration.Bioactive materials · 2026Article
- Bioadhesive-Integrated 3D-Printed Multilayer Scaffolds Secure a Mechanically-Stable Osteoimmune Niche for Enhanced Bone Augmentation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration.Bioactive materials · 2026Review
- Diabetic Wound Healing Enabled by a Tri-Functional MAX Phase via Cu Doping.Advanced healthcare materials · 2026Article
- A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.Bioactive materials · 2026Article
- Advances in GelMA Hydrogel-Enabled Angiogenic-Osteogenic Coupling: From Structural Programming to Exogenous Cue Synergy.Journal of functional biomaterials · 2026Review
- High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential.Materials today. Bio · 2026Review
- Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants.Materials today. Bio · 2026Article
- Targeting the PGRN-BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Piezoelectric heterojunction/polyetherketoneketone composite with enhanced sonodynamic efficacy and nanozyme activities for anti-infection and encouraging neurovascular ossification.Journal of nanobiotechnology · 2026Article
- Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Pseudo-Mytilus Edulis Foot Protein-Based Hydrogel Adhesive with Osteo-Vascular-Immune Coupling Effects for Osteoporotic Bone-Implant Integration.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Construction of chiral ZnO/BMP-2 dual functional coating on the surface of Ti implants for anti-infection and enhancement of osseointegration.Frontiers in bioengineering and biotechnology · 2026Article
- AI-driven biomaterial design: an intelligent closed loop from reverse design to biological response.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The reduced initial stability of orthopedic implants in osteoporotic bone matrices, coupled with excessive M1 macrophage polarization at bone-implant interfaces, disrupt bone-immune homeostasis and vascularization, ultimately leading to implant loosening or failure. Inspired by the marine mussel Mytilus edulis foot protein (Mefp), a pH-responsive multifunctional bone glue (YDC-Gel-Zn) with broad-spectrum adhesion capabilities is developed for osteoporotic bone-implant integration. This pseudo-Mefp bioglue enables dual-interface adhesion via catechol-rich sequences that mediate stable metal-phenolic coordination with metallic implants and hydrogen-bonded/Michael addition-driven interactions with the bone matrix, thereby improving initial implant fixation. Under osteoporotic inflammatory microenvironments, sequential dissociation of borate ester bonds and metal‒phenolic coordination facilitates the controlled release of Zn
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.