Evidence map›Paper›PMID 41190930›Full record

ReviewJournal of bacteriology2025

The Thermococcales as a model system: historical perspectives and emerging tools.

Alina M Galyon, Haruyuki Atomi, Thomas J Santangelo

Abstract readReviewHistorical Article
In one paragraph

Review in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alina M GalyonDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0009-0004-3228-4121
Haruyuki AtomiDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto, Japan.ORCID 0000-0001-9687-6426
Thomas J SantangeloDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0003-4559-3244

Funding

Regulation of Archaeal TranscriptionR35GM143963 · NIGMS · COLORADO STATE UNIVERSITY · PI Thomas James Santangelo · 2022 to 2026
$1.8M
Japan Society for the Promotion of Science JP25H00432NASA 80NSSC23K1354National Science Foundation 2016857National Science Foundation 2022065NIGMS NIH HHS R35 GM143963NIH HHS R35GM143963U.S. Department of Energy DE-SC0014597
6 · The paper itself

Abstract

Thermococcales are among the most widely studied hyperthermophilic Archaea and have become key models for understanding life at extreme temperatures. Early work in the 1980s culminated in the isolation of novel Thermococcales species from hydrothermal vents that grew rapidly, tolerated extreme heat, and metabolized diverse substrates, making them uniquely amenable for laboratory studies. Their thermostable enzymes and emerging genetic tools facilitated detailed investigations of core processes such as DNA replication, repair, and transcription under conditions that challenge most life forms. These practical advantages, together with the accumulation of tools and protocols, cemented the role of Thermococcales as a model system. Here, we recount how chance discoveries, environmental adaptations, and experimental practicality intersected to establish Thermococcales as a central model for studying archaeal biology and extremophile physiology.

Indexed as

ArchaeaDNA ReplicationHistory, 20th CenturyHistory, 21st CenturyHot TemperatureArchaeahyperthermophilePalaeococcusPyrococcusThermococcusthermophile

Identifiers

PMID41190930
PMCPMC12713403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.