Evidence map›Paper›PMID 41190921›Full record

ArticleBiomaterials science2026

Enabling global access to potent subunit vaccines with a simple and scalable injectable hydrogel platform.

Priya Ganesh, Alexander N Prossnitz, Carolyn K Jons, Noah Eckman, Alakesh Alakesh, Ye Eun Song, Samya Sen, Eric A Appel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priya GaneshDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0009-0000-4020-7100
Alexander N ProssnitzDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0002-1857-6943
Carolyn K JonsDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0003-2322-6726
Noah EckmanDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4183-0153
Alakesh AlakeshDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0001-8038-0434
Ye Eun SongDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0001-8764-8077
Samya SenDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0003-3043-8217
Eric A AppelDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID http://orcid.org/0000-0002-2301-7126

Funding

30-parameter FACSymphony A3 flow cytometer for Shared Resource LabS10OD026831 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2019 to 2019
$510k
Gates Foundation INV-027411NIH HHS S10 OD026831
6 · The paper itself

Abstract

Vaccines have been crucial to dramatic improvements in global health in recent decades, yet next-generation vaccine technologies remain out of reach for much of the world. In particular, there are two overarching global needs: (i) develop vaccines eliciting more potent and durable immune responses, especially to reduce incidence of highly communicable diseases, and (ii) enable simple and cost-efficient formulation to maximize global access. Here, we develop an injectable hydrogel depot technology prepared through physical mixing of commercially available, generally recognized as safe (GRAS) polymers that can be formulated with subunit vaccine components to improve immune responses compared to standard vaccine formulations. We demonstrate that these hydrogels are shear-thinning and rapidly self-healing, enabling facile administration

Indexed as

COVID-19 VaccinesHydrogelsInfluenza VaccinesVaccines, SubunitAnimalsCOVID-19FemaleHumansInfluenza A Virus, H5N1 SubtypeInjectionsMiceMice, Inbred BALB CSARS-CoV-2COVID-19 VaccinesHydrogelsInfluenza VaccinesVaccines, Subunit

Identifiers

PMID41190921
PMCPMC12832181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.