Evidence map›Paper›PMID 41190894›Full record

ReviewChannels (Austin, Tex.)2025

Orai storeoperated Ca

Bernard T Drumm, Neha Gupta

Abstract readReview
In one paragraph

Review in Channels (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bernard T DrummSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Ireland.ORCID 0000-0002-4762-844X
Neha GuptaSmooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the European Union, urinary incontinence (UI) affects 45% of adults during their lifetime, representing a major clinical and socio-economic burden. Failure of urethral smooth muscle (USM) to contract normally (hypo or hypercontractility) contributes to UI symptoms such as urine leakage during bladder filling or inability to urinate due to obstruction. Adequate UI treatments are lacking, partially due to a lack in understanding of cellular mechanisms underlying USM contraction. USM contractions rely on Ca

Indexed as

Calcium ChannelsMuscle ContractionMuscle, SmoothORAI1 ProteinUrethraAnimalsCalciumCalcium SignalingHumansCalciumCalcium ChannelsORAI1 ProteinCa2+ channelincontinenceOraisarcoplasmic reticulumsmooth muscleSOCESTIMstore operatedurethra

Identifiers

PMID41190894
PMCPMC12591592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.