ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
The activity of hippocampal place cells is essential for various processes of spatial memory, including encoding, consolidation, and retrieval. However, whether they also participate in spatial memory updating remains elusive. This study demonstrates that during the process of long-term spatial associative memory updating, triggered by changes in reward magnitudes in a maze over consecutive days, there is a distinct period characterized by loss of preference for different reward magnitudes before adapting to new magnitude ratios. During this period, sequential replays in the hippocampus during post-training sleep are significantly biased toward the region associated with the larger reward. Additionally, replays between trials show elevated predictive power for the upcoming choices. Our results suggest that hippocampal replays may play a key role in updating long-term spatial associative memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.