Evidence map›Paper›PMID 41190779›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Investigating Metal and Fluorophore Controlled Intracellular Localization in Noble Metal Thiosemicarbazone Complexes.

Nandan Sheernaly, Axel Steinbrueck, Nicolas Krahn, Christoph Rumancev, Frank Peeters, Lejla Jusufagic, Jasmine Ochs, Jan Garrevoet, Gerald Falkenberg, Axel Rosenhahn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nandan SheernalyFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0009-0008-9343-8429
Axel SteinbrueckFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0000-0001-6014-3204
Nicolas KrahnFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0009-0005-2821-9316
Christoph RumancevFaculty of Chemistry and Biochemistry, Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0000-0003-0286-506X
Frank PeetersFaculty of Biology and Biotechnology, Applied Microbiology, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0009-0009-9469-8238
Lejla JusufagicFaculty of Chemistry and Biochemistry, Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.
Jasmine OchsFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.
Jan GarrevoetDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, Hamburg, 22607, Germany.ORCID https://orcid.org/0000-0001-8696-0499
Gerald FalkenbergDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, Hamburg, 22607, Germany.ORCID https://orcid.org/0000-0002-2229-1027
Axel RosenhahnFaculty of Chemistry and Biochemistry, Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0000-0001-9393-7190
Nils Metzler-NolteFaculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, Bochum, 44801, Germany.ORCID https://orcid.org/0000-0001-8111-9959

Funding

Bundesministerium für Bildung und Forschung 05K19PC2Deutsche Forschungsgemeinschaft 518777768Deutsche Forschungsgemeinschaft 525502632Deutsche Forschungsgemeinschaft GRK 2341Fonds der Chemischen Industrie
6 · The paper itself

Abstract

Transition metal complexes have been widely utilized as cellular imaging tools. To impart organelle specificity, ligand architecture is usually modified to modulate properties like overall charge and lipophilicity. In many such designs, the metal identity and its intrinsic properties are often ignored. To address this gap, in this study, we explored the effects of changing the metal center on the localization patterns of isostructural complexes. To this end, we employed the thiosemicarbazone Dp44mT to synthesize coumarin-conjugated complexes of Au(III), Pt(II), and Pd(II). Although the metal centers in these compounds share a formal d

Indexed as

Coordination ComplexesFluorescent DyesThiosemicarbazonesBoron CompoundsCoumarinsGoldHeLa CellsHumansLigandsPalladiumPlatinum4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsCoordination ComplexescoumarinCoumarinsFluorescent DyesGoldLigandsPalladiumPlatinumThiosemicarbazonesconfocal microscopydp44mtfluorophore conjugatesimaginginorganic chemical biologylocalization patternsmetal complexesthiosemicarbazonesx‐ray fluorescence imaging

Identifiers

PMID41190779
PMCPMC12699179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.