ArticleAmerican journal of hematology2026
Hospital Variations in Time-To-Crisis-Resolution Among Children and Adolescents With Sickle Cell Disease.
Registry-linked trialAbstract readLetter
In one paragraph
Article in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04839354 (Sickle Cell Disease Treatment With Arginine Therapy), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Chris A ReesDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-6449-0377
Dunia HatabahDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0006-6685-2902
Rawan KormanDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0009-9780-9589
Fahd AhmadDivision of Pediatric Emergency Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-5919-6835
Gladstone AireweleTexas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Bolanle AkinsolaDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Noor AlzraikatDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-7139-6845
Nitya BakshiDivision of Pediatric Hematology-Oncology, Yale School of Medicine, New Haven, Connecticut, USA.
David C BrousseauDepartment of Pediatrics, Nemours Children's Health Delaware and the Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, Delaware, USA.
Kathleen BrownDivision of Emergency Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Andrew D CampbellDivision of Emergency Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0002-8829-0043
T Charles CasperDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Todd P ChangDivision of Pediatric Emergency Medicine, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, California, Los Angeles, USA.
Corrie E ChumpitaziDivision of Emergency Medicine, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Daniel CohenDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Keli D ColemanSection of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-7135-9569
Andrea T CruzTexas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Christopher DentonDivision of Pediatric Emergency Medicine, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, California, Los Angeles, USA.ORCID 0000-0003-3070-1775
Angela EllisonDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Melanie E FieldsDivision of Pediatric Emergency Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-6223-4468
Monica HardingDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Sara LeibovichDepartment of Emergency Medicine, University of California, San Francisco, California, USA.
Allison RemikerSection of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, Wisconsin, USA.
Nidhi V SinghTexas Children's Cancer and Hematology Centers, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Alexis A ThompsonDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Elliott VichinskyCenter for Maternal-Fetal Precision Medicine, University of California, San Francisco, California, USA.
Anthony VillellaDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Bridget WynnDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Carlton DampierDepartment of Pediatrics, Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Claudia R MorrisDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-6019-2858
Pediatric Emergency Care Research Network (PECARN)
Funding
1/2 Sickel Cell Disease Treatment with Arginine Therapy (STArT Trial)UH3HL148560 · NHLBI · EMORY UNIVERSITY · PI MORRIS, CLAUDIA R · 2021 to 2025
$6.9M2/2: Sickle Cell Disease Treatment with Arginine Therapy (STArT) trialU24HL148563 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CASPER, THERON C · 2020 to 2025
$3.5MPatient-Oriented Research in Arginine Deficiency SyndromesK24AT009893 · NCCIH · EMORY UNIVERSITY · PI Claudia R Morris · 2018 to 2026
$1.5MAdvancing Approaches to Identify Young Children at Risk for Post-Discharge MortalityK23HL173694 · NHLBI · EMORY UNIVERSITY · PI Christopher A. Rees · 2024 to 2026
$585kDoris Duke Charitable Foundation COVID19 Fund to Retain Clinical Scientists-PeRSEVERE Program at Emory University School of Medicine, and the Georgia Clinical and Translational Science Alliance 5U24HL148563Doris Duke Charitable Foundation COVID19 Fund to Retain Clinical Scientists-PeRSEVERE Program at Emory University School of Medicine, and the Georgia Clinical and Translational Science Alliance UL1-TR002378Maternal and Child Health Bureau U03MC00001Maternal and Child Health Bureau U03MC00007Maternal and Child Health Bureau U03MC22684Maternal and Child Health Bureau U03MC28844Maternal and Child Health Bureau U03MC33154Maternal and Child Health Bureau U03MC33156Maternal and Child Health Bureau U03MC49671Maternal and Child Health Bureau UJ5MC30824NCCIH NIH HHS AT009893NCCIH NIH HHS K24 AT009893NHLBI NIH HHS 1K23HL140142NHLBI NIH HHS 1K23HL140142-03S1NHLBI NIH HHS 5UH3HL148560NHLBI NIH HHS K23 HL173694NHLBI NIH HHS K23HL173694NHLBI NIH HHS U24 HL148563NHLBI NIH HHS UH3 HL148560
Abstract
Analysis of the placebo cohort in the STArT trial shows that patient characteristics and hospital site strongly influence time-to-crisis-resolution and total opioid use in children and young adults with sickle cell disease, highlighting the need to account for these factors in the design of future clinical trials.
Indexed as
Analgesics, OpioidAnemia, Sickle CellHospitalsAdolescentAdultChildChild, PreschoolFemaleHumansMaleTime FactorsYoung AdultAnalgesics, Opioidargininesickle cell diseasesickle cell disease treatment with arginine therapy (STArT)time‐to‐crisis‐resolutionvaso‐occlusive pain episodes
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT04839354ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.