Evidence map›Paper›PMID 41190751›Full record

ArticleACS nano2025

Virus-Inspired mRNA Delivery Vehicle Enabled by a Multilayered Nucleic Acid Nanocapsule.

Suman Pal, Divya Singla, Rachelle C Canete, Joseph B Darkwah, Jenna N Cannata, Morgan L Hunte, Isabel B Penales, Steven M Szczepanek, Frédéric Ducongé, Henry M Smilowitz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Investigating theBioconjugate chemistry · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Suman PalDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.ORCID 0000-0003-3852-4857
Divya SinglaDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.ORCID 0009-0004-4919-996X
Rachelle C CaneteDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.ORCID 0009-0007-8653-3164
Joseph B DarkwahDepartment of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Rd, Storrs, Connecticut 06269, United States.
Jenna N CannataDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.
Morgan L HunteDepartment of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Rd, Storrs, Connecticut 06269, United States.
Isabel B PenalesDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.ORCID 0009-0008-5141-3725
Steven M SzczepanekDepartment of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Rd, Storrs, Connecticut 06269, United States.
Frédéric DucongéCEA Fundamental Research Division (DRF), Molecular Imaging Research Center (MIRCen), Institute of Biology François Jacob, 18 Route du Panorama, Fontenay-aux-Roses 92265, France.ORCID 0000-0002-8595-0050
Henry M SmilowitzDepartment of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, Connecticut 06030, United States.
Jessica L RougeDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, Connecticut 06269, United States.ORCID 0000-0002-6051-3735

Funding

Achieving enhanced cytosolic delivery and greater efficacy of therapeutic nucleic acids using DNA-surfactant conjugatesR35GM138226 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Jessica L Rouge · 2020 to 2026
$2.4M
NIGMS NIH HHS R35 GM138226
6 · The paper itself

Abstract

The chemical instability of mRNA complicates its future clinical application, including issues surrounding its storage, handling, and potential for delivery to patients. Herein, we describe a chemical formulation, inspired by the dynamic multidimensional structure of a virus, with the potential to address many mRNA delivery limitations by enhancing stability, effective cytosolic delivery, and enabling the ability to target mRNA expression to a specific cell receptor. It consists of a liposomal core, stabilized by a metal organic framework, encapsulated within our nucleic acid nanocapsule formulation, ultimately imparting an enzymatic trigger to gate mRNA release and expression in cells, much as a virus is degraded by proteolytic enzymes under acidic conditions in the endosome to release its genetic cargo. We refer to this formulation as a liposomal metal organic framework-nucleic acid nanocapsule, wherein we show how a multilayered delivery carrier can use both pH and enzyme-specific triggers to gate efficient mRNA delivery to the cytosol of cells

Indexed as

NanocapsulesNucleic AcidsRNA, MessengerAnimalsHumansLiposomesMetal-Organic FrameworksMiceLiposomesMetal-Organic FrameworksNanocapsulesNucleic AcidsRNA, Messengeraptamerenzyme-responsiveintracellular deliverymRNAnanocarrier

Identifiers

PMID41190751
PMCPMC12715816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.