Evidence map›Paper›PMID 41190655›Full record

ArticlemBio2025

LPS O-antigen polysaccharide length impacts outer membrane permeability of enteric gram-negative bacteria.

Kerrie L May, Tatsuya Akiyama, Bella G Parker, Minsu Kim, Marcin Grabowicz

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kerrie L MayDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-4302-2440
Tatsuya AkiyamaEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Bella G ParkerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Minsu KimEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-1594-4971
Marcin GrabowiczDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-8000-2222

Funding

Single Cell Analysis Core (Core C)U19AI158080 · NIAID · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD, WEISS, DAVID S · 2021 to 2025
$10.9M
INfectious Diseases Summer Program Integrating Research at Emory (INSPIRE)R25AI175048 · NIAID · EMORY UNIVERSITY · PI ANITA H. CORBETT, Michael Hoonbae Chung · 2024 to 2026
$1.1M
Lipoprotein trafficking to the bacterial outer membraneR35GM156739 · NIGMS · EMORY UNIVERSITY · PI Marcin Grabowicz · 2025 to 2026
$875k
NIAID NIH HHS R25 AI175048NIAID NIH HHS U19 AI158080NIGMS NIH HHS R35 GM156739
6 · The paper itself

Abstract

The gram-negative outer membrane (OM) forms the bacterial cell surface and acts as a barrier against antibiotic influx. In enteric species, the OM is covered by lipopolysaccharides (LPS) decorated with varying lengths of O-antigen (O-Ag) polysaccharide that protect bacteria against mammalian host defenses. Studies of lab-adapted IMPORTANCE: The outer membrane (OM) of bacteria like

Indexed as

Bacterial Outer MembraneCell Membrane PermeabilityEscherichia coli K12LipopolysaccharidesO AntigensShigella flexneriAnti-Bacterial AgentsGram-Negative BacteriaMicrobial Sensitivity TestsAnti-Bacterial AgentsLipopolysaccharidesO Antigensantibioticscell envelopecell wallenvelope stresslipopolysaccharideO-antigenouter membrane

Identifiers

PMID41190655
PMCPMC12691688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.