ArticleMenopause (New York, N.Y.)2026
The burden of sleep disturbances on quality of life and mental well-being in nearly 50,000 perimenopausal and postmenopausal women with and without concurrent vasomotor symptoms from the United States and Europe.
Article in Menopause (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Trial
- Sleep Disruption in the Menopausal Transition and Postmenopause: A Narrative Review.Obstetrics and gynecology · 2026Review
- Sleep pattern differences in women at midlife: a large-scale multi-country smartwatch study (SONAR).Sleep · 2026Article
- Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood-Brain Barrier Dysfunction in Female Wistar Rats.Neurochemical research · 2026Article
- Beyond Menopausal Stage: Symptom Burden, Self-Efficacy, and Psychological Distress.Journal of clinical medicine · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo quantify the burden of sleep disturbances on health-related quality of life (HRQoL) and mental well-being in perimenopausal and postmenopausal women with/without co-occurring vasomotor symptoms (VMS).
methodsPerimenopausal and postmenopausal women aged 40 to 65 years who participated in the National Health and Wellness 2019/2021 (US; N=27,621) and 2017/2020 cross-sectional surveys (France, Germany, Italy, Spain, UK; N=20,220) were included. Patient-reported outcomes were HRQoL (Short-Form Health Survey physical and mental component summary scores, EuroQol Visual Analogue Scale, EQ-5D-5L), depression (Patient Health Questionnaire-9), and anxiety (Generalized Anxiety Disorder-7 assessment). Associations between self-reported sleep disturbances and/or VMS and study outcomes were evaluated using generalized multivariable linear regression.
resultsAmong perimenopausal women, sleep disturbances were reported by 61.7% (US) and 60.6% (Europe) with VMS, and 38.0% (US) and 40.8% (Europe) without VMS. Among postmenopausal women, sleep disturbances were reported by 66.7% (US) and 63.4% (Europe) with VMS, and 44.5% (US) and 40.9% (Europe) without VMS. Compared with women with neither symptom, perimenopausal and postmenopausal women with sleep disturbances had worse HRQoL ( P <0.001) and higher (worse) depression and anxiety scores ( P <0.05 perimenopausal, P <0.001 postmenopausal) irrespective of VMS. In addition, among postmenopausal women, those with sleep disturbances alone had worse HRQoL and higher (worse) depression and anxiety scores than those with VMS alone ( P <0.001).
conclusionsSleep disturbance was common among perimenopausal and postmenopausal women irrespective of VMS, and independently associated with negative effects on HRQoL, depression, and anxiety. Effective treatments for sleep disturbances and VMS in menopausal women are needed to mitigate the associated burden and improve well-being.
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