ArticleInternational journal of surgery (London, England)2026
Appraisal the significance of completion hysterectomy after definitive concurrent chemoradiotherapy for patients with locally advanced cervical adenocarcinoma: the ATTRACT study.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo appraise whether the completion hysterectomy after concurrent chemoradiotherapy (CCRT) would improve the survival outcomes for patients with locally advanced cervical adenocarcinoma (LACA).
methodsThis study was conducted based on a large cohort including more than 200 LACA patients from Peking Union Medical College Hospital. The included patients were divided into the CCRT alone and CCRT + surgery groups, where overall survival (OS), progression-free survival (PFS), loco-regional-free survival (LRFS), and distant metastasis-free survival (DMFS) were compared between the two groups before and after propensity scoring matching (PSM). Cox regression analysis was performed in the CCRT alone group to identify the risk factors impairing the survival probability. The survival outcomes were further compared between the CCRT alone and the CCRT + surgery group in different risk subgroups identified from Cox regression analysis.
resultsCCRT + surgery was observed to outperform CCRT alone in OS, PFS, LRFS, and DMFS before PSM (all P < 0.05), while the benefit of surgery could not be maintained after PSM except for DMFS (3-year DMFS: 76.8 vs. 60.2%, P = 0.035). Uterus involvement (UI) was identified as the only risk factor for the CCRT alone group. Surgery was found to increase the survival probability for patients with UI (all P < 0.05), while it did not bring additional survival benefit for patients without UI (all P > 0.05). In the CCRT + surgery group, patients with pathological residual disease (RD) ≥ 1/2 myometrial infiltration (MI) had significantly decreased survival compared to patients with RD<1/2MI or patients without RD (all P < 0.05). Furthermore, postoperative chemotherapy didn't improve survival outcomes in patients with RD<1/2MI, while it seemed to bring additional benefit for patients with RD≥1/2MI in terms of PFS with marginal significance ( P = 0.055).
conclusionCompletion hysterectomy after CCRT could increase DMFS for LACA patients, while not every LACA patient would retain OS benefit from surgery, except for those with positive UI. Survival differences existed in different degrees of RD among patients receiving post-radiation surgery and postoperative chemotherapy, demonstrating a trend toward PFS benefit for patients with RD≥1/2MI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.