Evidence map›Paper›PMID 41190326›Full record

ArticleFrontiers in genetics2025

Case Report: Clinical and molecular features of a radiosensitive autoimmune polyendocrine syndrome type 1 patient with oral carcinoma.

Asma Chikhaoui, Houda Hammami-Ghorbel, Dorra Najjar, Semia Zarraa, Safia Yahiaoui, Davor Lessel, Houda Yacoub-Youssef

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Asma ChikhaouiLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis ElManar, Tunis, Tunisia.
Houda Hammami-GhorbelDepartment of Dermatology, Habib Thameur Hospital (LR12SP03), Faculty of Medicine, University of Tunis ElManar, Tunis, Tunisia.
Dorra NajjarLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis ElManar, Tunis, Tunisia.
Semia ZarraaDepartment of Radiotherapy, Salah, Azaiz Institute, Tunis, Tunisia.
Safia YahiaouiDepartment of Radiotherapy, Salah, Azaiz Institute, Tunis, Tunisia.
Davor LesselInstitute of Human Genetics, University Regensburg, Regensburg, Germany.
Houda Yacoub-YoussefLaboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Université Tunis ElManar, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune polyendocrine syndrome type-1 (APS1), also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is an autoimmune genetic disease characterized by multiple endocrine disorders, chronic mucocutaneous candidiasis, and various ectodermal defects. Untreated candidiasis can increase the risk of oral cancer due to recurrent fungal infections. Radiotherapy is a curative option that can trigger an antitumoral response. However, exaggerated radiation-induced cytotoxicity can hinder this curative modality. APECED is caused by loss-of-function mutations in the autoimmune regulator

Indexed as

AIREautoimmune polyendocrine syndrome type-1cerebral cavernous malformationsMAP3K3oral carcinomaradiation-induced cytotoxicity

Identifiers

PMID41190326
PMCPMC12582548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.