SynthesisFrontiers in oral health2025
The efficacy of lactic acid bacteria-based toothpaste on oral health: a systematic review and meta-analysis.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis.Journal of clinical periodontology · 2026Article
- Compatibility of toothpastes with probiotics for periodontal health: anFrontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Lactic acid bacteria (LAB) have emerged as promising adjunctive agents for oral health management due to their antimicrobial and immunomodulatory properties. With the increasing incorporation of probiotics into oral care products, it is critical to evaluate their clinical efficacy. This systematic review and meta-analysis aimed to assess the effectiveness of LAB-based toothpaste in improving oral health outcomes. Methods: Following PRISMA guidelines, five databases (MEDLINE, EMBASE, Scopus, Web of Science, and CENTRAL) were searched through February 2025. Randomized controlled trials (RCTs) evaluating toothpastes containing probiotic, prebiotic, synbiotic, or postbiotic agents were included. Primary outcomes included plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL). Secondary outcomes assessed oral microbiota changes. Risk of bias was evaluated using the RoB 2 tool. Results: Twelve RCTs were included, with four studies suitable for meta-analysis. Meta-analysis demonstrated significant plaque reduction at 3 months [Mean Difference (MD) = -0.64; 95% confidence interval (CI): -1.14 to -0.15; Conclusions: LAB-based toothpaste demonstrates beneficial effects on plaque control and gingival inflammation. However, substantial heterogeneity (I Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420250650340, PROSPERO CRD420250650340.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.