ArticleDEN open2026
Intramucosal Alpha-Fetoprotein-producing Early Gastric Cancer Without Vascular Invasion or Metastasis Diagnosed After Endoscopic Submucosal Dissection: A Case Report and Literature Review.
Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Molecular pathogenesis and novel therapeutic avenues in alpha-fetoprotein-producing gastric cancer.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare histological subtype of gastric cancer that is often diagnosed at an advanced stage. In the present case, an elevated lesion was detected in the gastric antrum during upper gastrointestinal endoscopy screening and diagnosed as early gastric cancer of cT1a. The patient underwent endoscopic submucosal dissection (ESD), and pathological examination showed positive staining for AFP, leading to a diagnosis of AFPGC confined to the intramucosa (pT1a). An additional laparoscopic distal gastrectomy with lymphadenectomy was performed, which revealed no residual tumor and no lymph node metastasis. The patient has remained recurrence-free for 4 years after the additional surgery. Intramucosal gastric cancer with AFP production is extremely rare, and limited data are available regarding the need for additional surgical resection after ESD. Notably, a previous case of metastatic recurrence in AFPGC of cT1a was reported. Therefore, treatment decisions should be made on the basis of a thorough discussion and the patient's full informed consent.
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Registered trials
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