ArticleFrontiers in aging neuroscience2025
Peripheral immunity patterns, imaging features, and clinical outcomes in patients with gait impairment and ventriculomegaly on brain MRI.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Differential diagnosis of non-hydrocephalus ventricular dilation and hydrocephalus.Frontiers in neurologyReview
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9 authors.
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Abstract
Introduction: Ventricular enlargement is a common finding on brain MRI in patients with gait impairment, particularly in those with idiopathic normal pressure hydrocephalus (iNPH). However, iNPH shares several clinical and radiological features with neurodegenerative diseases, which complicates accurate diagnosis. This study aimed to explore the associations between peripheral immune markers, imaging biomarkers, and final diagnosis in patients with gait disturbance and ventriculomegaly. Methods: We retrospectively analyzed 55 patients with gait impairment and ventriculomegaly, and 40 age-comparable healthy controls. Clinical assessments included the iNPH Grading Scale (iNPHGS) and cognitive tests. The neutrophil-to-lymphocyte ratio (NLR) was calculated as a peripheral immune marker. Imaging biomarkers included Evans' index (EI), callosal angle (CA), and disproportionately enlarged subarachnoid space hydrocephalus (DESH) score. Additional cerebrospinal fluid biomarkers and [ Results: ND patients had significantly higher NLR ( Conclusion: NLR may serve as a promising peripheral biomarker to differentiate ND from iNPH in patients with gait impairment and ventriculomegaly. Integrating immune, clinical, and imaging markers could improve diagnostic accuracy and guide appropriate therapeutic strategies.
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