Evidence map›Paper›PMID 41190159›Full record

ArticleFrontiers in nutrition2025

CT-Based assessment of sarcopenia and its association with biologic treatment outcomes in Chinese Children with Crohn's disease.

Cheng Guo, Yan Kong, Guoli Wang, Junye Du, Chang Yu, Jie Wu

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In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng Guo *Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yan Kong *Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Guoli WangDepartment of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Junye DuDepartment of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Chang YuDepartment of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jie WuDepartment of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia affects treatment outcomes in patients with Crohn's disease (CD), yet research focusing on pediatric populations is limited. This study aimed to determine the prevalence of sarcopenia among Chinese children with CD and to evaluate its impact on biologic therapy by analyzing body composition parameters based-on computed tomography enterography (CTE). Methods: Pediatric CD patients who underwent CTE and received infliximab (IFX) treatment between 2022 and 2025 were enrolled. Clinical, laboratory, and radiological data were collected. CTE was utilized to assess body composition. The control group consisted of children without inflammatory bowel disease (non-IBD) who underwent abdominal CT scans. Results: A total of 68 children with CD (mean age 11.89 years) were included. The prevalence of sarcopenia was significantly higher in the CD group compared to the 136 controls (33.8% vs. 10.2%, Conclusion: Sarcopenia is common in Chinese children with CD and adversely affects the efficacy of biological therapy. CTE is a valuable tool for assessing sarcopenia in this population. Early detection and intervention may improve clinical outcomes for children with CD.

Indexed as

body compositionchildrencomputed tomography enterographyCrohn's diseaseinfliximabsarcopenia

Identifiers

PMID41190159
PMCPMC12580624

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.