ArticleRegenerative biomaterials2025
A pro-angiogenic wound dressing embedded with natural spider silk protein.
Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Beyond wound closure: translational opportunities and barriers of mesenchymal stem cells and their extracellular vesicles in burn management.Frontiers in cell and developmental biology · 2026Review
- An electroactive platform enabled by near-field communication for accelerating infected diabetic wound healing via directional electric field reshaping and immunomodulation.Regenerative biomaterials · 2026Article
- Decellularization of porcine dermis via supercritical CORegenerative biomaterials · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Angiogenesis plays a pivotal role in the wound healing process by supplying essential nutrients and oxygen to regenerating tissues thereby supporting tissue remodeling. Promoting the formation of new blood vessels is, therefore, a critical therapeutic strategy, particularly for ischemic and chronic wounds, where impaired blood supply often leads to delayed or incomplete healing. However, the development of effective pro-angiogenic biomaterials remains a challenge. In this work, by incorporating natural spider silk proteins (SSP) with poly(L-lactic acid) (PLLA) nanofiber via electrospinning, we developed a pro-angiogenic wound dressing. The incorporation of SSP led to a reduction in fiber diameter and the formation of a hierarchical structure that mimics the native extracellular matrix. Moreover, the combined effects of these biophysical and SSP-derived biochemical cues synergistically enhanced vascular regeneration, resulting in significant improvements in three key angiogenic parameters compared to pure PLLA controls: a 16.3% increase in blood vessel count, a 118.6% increase in vascular branching and a 32.8% increase in total vessel length.
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