Effectiveness and Safety of Mirabek Sustained-release 50 mg Tablets in Korean Patients with Overactive Bladder: A Multicenter Observational Study at Tertiary General Hospitals.

Background and objective: Mirabegron, a first-in-class β Methods: Adult patients with OAB newly prescribed Mirabek sustained-release 50 mg tablets were enrolled from 46 tertiary general hospitals. Assessments were performed at baseline and follow-up visits at 3 and 6 mo. Data collected included the OAB Symptom Score (OABSS), bladder diaries, uroflowmetry results, and adverse events. Key findings and limitations: Among the 4009 participants analyzed, 81.3% completed 6 mo of treatment. At 3 and 6 mo, 35.3% and 43.4% of participants, respectively, achieved a ≥3-point reduction in total OABSS ( Conclusions and clinical implications: Mirabek (generic mirabegron) demonstrated effective symptom relief and was well tolerated in Korean patients with OAB, with sustained efficacy up to 6 mo. The introduction of Mirabek substantially reduced treatment costs and expanded access to mirabegron therapy. Patient summary: In this study, we looked at the effect of Mirabek, a generic medication for overactive bladder (OAB), in >4000 Korean patients treated in large hospitals. We found that Mirabek improved bladder symptoms such as urgency and frequent urination over 6 mo, with very few side effects. Most patients stayed on the treatment and reported feeling better, suggesting that this affordable medication can help more people manage their OAB effectively.