Evidence map›Paper›PMID 41190020›Full record

ArticleFrontiers in pharmacology2025

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration.

Liya Liu, Peiyao Li, Youqin Chen, Guangqing Yang, Ying Cheng, Sijia Liu, Xinran Zhang, Yulun Wu, Qihong Liu, Peilin Zhao and 9 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Liya Liu *Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Peiyao Li *Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Youqin Chen *Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, United States.
Guangqing Yang *Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Ying ChengAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Sijia LiuAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xinran ZhangAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yulun WuAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Qihong LiuDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Peilin ZhaoDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Wenyi FangDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yan RenDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Lunan HuDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yanmin LiuShenzhen Wedge Microbiology Research Co., Ltd., Shenzhen, China.
Kangning LiShenzhen Wedge Microbiology Research Co., Ltd., Shenzhen, China.
Zhangran ChenShenzhen Wedge Microbiology Research Co., Ltd., Shenzhen, China.
Xiao KeDepartment of Gastroenterology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Qingquan LiDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Aling ShenAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-Strain Probiotic Combination (Golden Bifid), a probiotic formulation composed of

Indexed as

golden bifidgut microbiotaMAPK signaling pathwayRNA sequencingslow transit constipationthree-strain probiotic combination

Identifiers

PMID41190020
PMCPMC12580145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.