ArticleFrontiers in cardiovascular medicine2025
The association between blood pressure, renal function, and subclinical atherosclerosis in young and middle-aged non-hypertensive individuals: a mediation analysis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of blood urea nitrogen to high-density lipoprotein ratio with all-cause and cardiovascular mortality in individuals with mildly reduced eGFR.Clinics (Sao Paulo, Brazil) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to investigate the interactions between blood pressure, renal function, and subclinical atherosclerosis in young and middle-aged individuals without hypertension. Methods: A total of 1,590 young and middle-aged individuals without hypertension were selected from the Shanghai Health and Medical Center database. Univariate and multivariate regression analyses were used to identify risk factors associated with subclinical atherosclerosis, and a mediation analysis using the bootstrap method was conducted to assess the mediating role of renal function between blood pressure and subclinical atherosclerosis. Results: The multivariate linear regression analysis identified significant correlations with age, gender, diastolic blood pressure (DBP), systolic blood pressure (SBP), glomerular filtration rate (GFR), history of cardiovascular disease (CVD), glycated hemoglobin (HbA1c), smoking history, and brachial-ankle pulse wave velocity (baPWV) ( Conclusion: Renal function is independently associated with blood pressure and subclinical atherosclerosis after adjusting for confounders. Moreover, renal function mediates the relationship between blood pressure and subclinical atherosclerosis, also in males.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.