ArticleFrontiers in oncology2025
A multifunctional MRI model based on IVIM and DKI predicts HIF-1α, Ki-67, and VEGF status in breast carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The research aims to explore the predictive significance of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), and their integrated models in relation to Hypoxia-inducible factor-1 alpha (HIF-1α), Ki-67, and vascular endothelial growth factor (VEGF) expression levels in breast carcinoma. Materials and Methods: This retrospective study included 104 patients with pathologically confirmed breast carcinoma from our institution as the training set, while an external validation cohort of 91 eligible patients was recruited from another tertiary medical center. Two independently working radiologists analyzed IVIM-derived parameters apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (f), and DKI-derived parameters mean diffusivity (MD) and mean kurtosis (MK). Receiver operating characteristic (ROC) curves were constructed for evaluation of diagnostic efficacy. The outcomes of the multivariate logistic regression model were employed to create a nomogram of the combined model for molecular marker status prediction. Results: High expression levels of HIF-1α, VEGF, and Ki-67 were consistently associated with lower D, MD, and ADC values, and higher perfusion-related D*, f, and MK values (all P<0.05). ROC curve analysis showed that among the individual parameters, the D value exhibited the highest predictive efficacy (Area Under the Curve, AUC = 0.724). A D value ≤ 0.88×10 Conclusion: Our findings suggest that IVIM may be usefully combined with DKI to help predict the expression levels of Ki-67, HIF-1α, and VEGF in breast cancer, generating hypotheses for future research. Furthermore, the diagnostic efficiency of the parameters D* and f appears to be enhanced by employing more low b-values (<100-200 s/mm²). These results require confirmation in prospective, multi-center studies.
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