ArticleFrontiers in toxicology2025
Toxicological effects of sublethal microcystin-LR exposure in
Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Microcystins (MCs) are alarming aquatic contaminants having extensive health implications in fish. Despite growing concern, comprehensive studies on long term effects of MCs remain unexplored in Methods: Healthy rohu juveniles (mean weight 25 ± 2.1 g), sourced from institute farm were acclimatized for 2 weeks. The sublethal experimental study consisted of two treatments (control group: T0 and one-tenth 96 h-LD Results: MC-LR induced significant histological and ultrastructural alterations including vacuolation, hepatocyte degeneration, disintegration of heterochromatin, loss of nucleolus and mitochondrial swelling. It significantly ( Discussion: Based on these findings, it is deduced that even sublethal levels of MC-LR can disrupt intrinsic antioxidant defences, immune responses, and detoxification mechanisms in rohu, potentially compromising fish health in natural ecosystems. This is the first report to detail long-term impacts in rohu, elucidating the mechanism of damage induced by MC-LR and also providing valuable insights for environmental monitoring and toxin management.
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