Evidence map›Paper›PMID 41189793›Full record

ArticleRomanian journal of ophthalmology

A Case Series of Serious Adverse Events Following Anti-VEGF Intravitreal Injections.

Andreea Alexandra Mihaela Muşat, Nicoleta Zamfiroiu-Avidis, Cornel Ştefan, Schmitzer Andreea, Gabriela Muşat, Gabriela Udrea, Ioana Stella Popescu, Ovidiu Muşat

Abstract readCase Reports
In one paragraph

Article in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andreea Alexandra Mihaela Muşat"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Nicoleta Zamfiroiu-AvidisClinical Emergency Eye Hospital, Bucharest, Romania.
Cornel Ştefan"Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.
Schmitzer Andreea"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Gabriela Muşat"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Gabriela UdreaApel Laser SRL, Ilfov, Romania.
Ioana Stella Popescu"Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.
Ovidiu Muşat"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To highlight serious adverse effects regarding intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy, which is widely used for the treatment of retinal diseases, including two cases of post-injection endophthalmitis, one of which was complicated by rhegmatogenous retinal detachment, and one case of secondary cataract following a potentially unnecessary injection. Methods: A retrospective analysis of three cases that developed complications after intravitreal anti-VEGF therapy. Results: All cases resulted in a decline in best corrected visual acuity (BCVA) that required additional surgical procedures. Discussion: While intravitreal anti-VEGF therapy has become the standard in the treatment of various retinal pathologies, it is not without risks. This case series presents significant adverse outcomes, emphasizing the potential for severe anatomical and functional consequences. As the global volume of anti-VEGF intravitreal injections increases, so must our commitment to patient safety, precision in diagnosis, and ethical decision making. Conclusion: Although generally safe and commonly used in clinical practice, physicians must be aware of the risks of anti-VEGF therapy and must remain vigilant regarding patient selection and risk-benefit considerations.

Indexed as

Angiogenesis InhibitorsBevacizumabCataractEndophthalmitisRanibizumabRetinal DetachmentVascular Endothelial Growth Factor AVisual AcuityHumansIntravitreal InjectionsRetrospective StudiesTomography, Optical CoherenceAngiogenesis InhibitorsBevacizumabRanibizumabVascular Endothelial Growth Factor AAMD = age-related macular degenerationanti-VEGFanti-VEGF = anti-vascular endothelial growth factorBCVA = best corrected visual acuitycataractendophthalmitisIOL = intraocular lensIOP = intraocular pressureOD = right eyeOS = left eyeretinal detachmentRRD = rhegmatogenous retinal detachment

Identifiers

PMID41189793
PMCPMC12580672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.