Evidence map›Paper›PMID 41189771›Full record

ReviewRomanian journal of ophthalmology

Unusual ectasia following corneal cross-linking in a patient with keratoconus.

Lorena Azorin-Perez, Ana Hervas-Ontiveros, Javier Cañas-Costa, Marta Gema Solaz-Ruiz, Pablo Morales-Lopez, Enrique España-Gregori

Abstract readCase ReportsReview
In one paragraph

Review in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lorena Azorin-PerezLa Fe University and Polytechnic Hospital, Valencia, Spain.
Ana Hervas-OntiverosLa Fe University and Polytechnic Hospital, Valencia, Spain.
Javier Cañas-CostaLa Fe University and Polytechnic Hospital, Valencia, Spain.
Marta Gema Solaz-RuizLa Fe University and Polytechnic Hospital, Valencia, Spain.
Pablo Morales-LopezClinical and Surgical Institute of Ophthalmology, Valencia, Spain.
Enrique España-GregoriLa Fe University and Polytechnic Hospital, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Description of an unusual ectasia following corneal cross-linking (CXL) in a patient with keratoconus. Methods: Clinical case report and review of the literature. Results: We present a case of an unusual ectasia after corneal CXL in a patient with keratoconus. Discussion: This case reports the first known occurrence of corneal ectasia following epi-off CXL, a procedure typically used to halt the progression of ectatic disorders such as keratoconus. Although the standard protocol was followed, subtle technical variations or postoperative healing factors could have contributed to the outcome. Conclusions: This case underscores the need for ongoing vigilance in patient selection and follow-up in the context of CXL. The rare development of corneal ectasia post-CXL highlights a gap in our understanding of corneal biomechanics and the potential limitations of current diagnostic tools. More research is needed to refine patient screening methods and optimize treatment protocols to ensure the efficacy and safety of this widely used procedure.

Indexed as

CollagenCorneaCross-Linking ReagentsKeratoconusPhotochemotherapyCorneal Cross-LinkingCorneal TopographyDilatation, PathologicHumansPhotosensitizing AgentsRiboflavinUltraviolet RaysVisual AcuityCollagenCross-Linking ReagentsPhotosensitizing AgentsRiboflavinanterior segmentBCVA = best-corrected visual acuitycorneal ectasiacross-linkingCXL = cross-linkingectasiaepi-off = epithelium-offkeratoconusOD = Right eyeOS = Left eyeUVA = ultraviolet A

Identifiers

PMID41189771
PMCPMC12580676

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.