ReviewJournal of experimental orthopaedics2025
No long-term effect of 7-day computer-assisted cryotherapy treatment after total knee arthroplasty: A randomized controlled trial with 1-year follow-up.
Review in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- No long-term effect of 7-day computer-assisted cryotherapy treatment after total knee arthroplasty: A randomized controlled trial with 1-year follow-up.Journal of experimental orthopaedics · 2025Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Positive effects on pain and opioid use were found in the first post-operative week, but long-term effects are unclear. Since rapid recovery studies show that short-term benefits may have positive long-term effects, the aim of this study is to investigate if there are any late effects (until 1 year post-operative) of computer-assisted cryotherapy (CAC) after total knee arthroplasty (TKA) on knee function, pain and patient satisfaction. Methods: A single-centre non-blinded randomized controlled trial was performed, comparing a cryotherapy group and a regular post-operative care group after TKA. The cryotherapy group used computer-assisted cooling, with instructions for cooling several hours per day for the first seven post-operative days. Oxford knee scores (OKS) (0-48), Knee Injury and Osteoarthritis Outcome Score-Physical function Short form (KOOS-PS) scores (0-100) and numeric rating scale (NRS) pain scores (0-10) were scored pre-operative and 6 and 12 months post-operative. Anchor questions about self-perceived changes in daily functioning and pain (7-point Likert scale) and patient satisfaction (NRS, 0-10) were obtained at both post-operative time points. Results: A total of 102 patients were analyzed, 51 patients in both groups. OKS showed no significant difference between the cryotherapy and the regular care groups after 6 and 12 months (median 37.0 vs. 38.0 after 6 months and 40.0 for both groups after 12 months, Conclusions: This study showed that use of CAC for 7 days post-operative after TKA has no significant late effects (until 1 year post-operative) on functioning, pain and patient satisfaction. This could imply that the clinical benefits of 7 days of cryotherapy are too short to demonstrate longer-term effects. Limitations such as non-blinding and lack of objective outcome measures might have influenced the outcomes. Level of Evidence: Therapeutic study with level of evidence I.
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