Evidence map›Paper›PMID 41189724›Full record

ArticleResuscitation plus2025

The art of conducting a good pilot study: a discussion of the BETA-ARREST pilot trial.

Hanna L Hägglund, Sergio Cazorla-Calderón, Eline L Braekman, Amani Alenazi, Kasper Glerup Lauridsen

Abstract read
In one paragraph

Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanna L HägglundDepartment of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Sergio Cazorla-CalderónUniversity of Vic- Central University of Catalonia (UVic-UCC). Institute for Research and Innovation in Life Sciences and Health in Central Catalonia (IRIS-CC), Vic, Spain.
Eline L BraekmanDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Amani AlenaziWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Kasper Glerup LauridsenDepartment of Medicine, Randers Regional Hospital, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This journal club article was conducted as part of the 2024/25 Young ERC Resuscitation Science Masterclass. In this paper, we provide a critical appraisal of the BETA-ARREST trial "Landiolol for Refractory Ventricular Fibrillation in Out-of-hospital Cardiac Arrest: a Randomized, Double-blind, Placebo-controlled, Pilot Trial" by Gelbenegger et al. 2024, and discuss what constitutes a good pilot study.

Indexed as

LandiololMethodologyPilot studiesRefractory ventricular fibrillation

Identifiers

PMID41189724
PMCPMC12580598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.