ArticleFrontiers in cellular and infection microbiology2025
Early bacterial communities in the lower airways and intestines of caesarean section neonates with respiratory disease.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Acute lower respiratory tract infection (ALRTI) are one of the most severe diseases affecting neonates worldwide. Many bacterial pathogens that cause respiratory infections in neonates are common residents in the respiratory tract. Therefore, the aim is to determine the early bacterial community in the lower airways and intestines of neonates. Methods: Airway secretions, oral swabs, and fecal samples were collected from 19 neonates with acute respiratory tract infection and 2 control subjects. All three types of samples were amplified and sequenced using specific primer sets targeting the 16S rRNA gene. Results: Bacterial composition of the feces and airway secretions in the diseased neonates significantly differed from that of the neonates in the control group. The feces microbiota in the diseased neonates had accumulated Discussion: Insight into the source and stability of microbiota in the neonatal period might elucidate health or susceptibility for developing a respiratory disease. Microbiota analysis also promises to complement the present means of detecting respiratory pathogens.
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