Evidence map›Paper›PMID 41189668›Full record

ReviewTherapeutic advances in gastroenterology2025

Body surface gastric mapping facilitates the management of pediatric disorders of gut-brain interaction.

Gayl Humphrey, Haley Pearlstein, Binghong Xu, Gregory O'Grady, Armen Gharibans, Hayat Mousa

Abstract readReview
In one paragraph

Review in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gayl HumphreyDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-2837-5707
Haley PearlsteinDivision of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Binghong XuDivision of Gastroenterology, The Children's Hospital of Philadelphia, 3500 Civic Center Blvd, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0001-6660-3558
Gregory O'GradyDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Armen GharibansDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Hayat MousaDivision of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of gut-brain interaction (DGBI) are among the commonest contributors to disease burden in children, yet remain difficult to diagnose and treat, in part because available tests inadequately capture underlying mechanisms or link physiology to symptoms. Body surface gastric mapping (BSGM) is a next-generation, noninvasive electrophysiological technology that records high-resolution gastric slow-wave activity with simultaneous symptom logging. This review summarizes emerging evidence that BSGM may fill a key diagnostic gap in pediatric DGBI. After outlining the burden and multifactorial pathophysiology of pediatric DGBI, we compare alternative investigations-including electrogastrography, gastric emptying scintigraphy, and antroduodenal manometry-and highlight their limitations in pediatrics, including regarding reproducibility, accessibility, invasiveness, and symptom correlation. We then describe BSGM methodology, validated spectral metrics, symptom integration, and standardized testing protocols. Early pediatric studies have demonstrated excellent feasibility, particularly in adolescents, established preliminary normative ranges, and identified phenotypes to distinguish neuromuscular disorders, delayed meal responses, and alternative symptom profiles to help inform targeted care. Concordance with antroduodenal manometry is also discussed. Finally, we outline research priorities, including the need for larger multicenter cohort studies, formalization of pediatric-specific reference intervals, and longitudinal studies assessing treatment responses. BSGM shows potential as a valuable noninvasive diagnostic tool for better characterizing pediatric DGBIs, though further validation is required.

Indexed as

adolescencebody surface gastric mapping (BSGM)diagnosticsdisorders of gut–brain interaction (DGBI)pediatricphenotypes

Identifiers

PMID41189668
PMCPMC12580533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.