Evidence map›Paper›PMID 41189629›Full record

ArticleFrontiers in human neuroscience2025

The effects of amplitude modulated transcranial alternating current stimulation on working memory of college students.

Heng Wang, Yan Chen, Ziyu Zhou, Rui Jiang, Haowei Hu, Yan Zhao, K Dimyati, Shen Tong, Ji Wang, Xiao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng Wang *School of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.
Yan Chen *School of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.
Ziyu Zhou *Information Center, Chengdu Second People's Hospital, Chengdu, China.
Rui JiangSchool of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.
Haowei HuSchool of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.
Yan ZhaoXuzhou Jiazhi Technology Co., LTD, Xuzhou, China.
K DimyatiDepartment of Electrical Engineering, Faculty of Engineering, Centre of Advanced Communication Research and Innovation, Universiti Malaya, Kuala Lumpur, Malaysia.
Shen TongSchool of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.
Ji WangDepartment of Children Healthcare, Xuzhou Children's Hospital, Xuzhou, China.
Xiao ZhangSchool of Medical Information and Engineering, Xuzhou Medical University, Xuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent studies suggest that amplitude-modulated transcranial alternating current stimulation (AM-tACS) may enhance cognitive functions, but its mechanisms and optimal application remain unclear. Methods: Thirty-three healthy university students were randomly assigned to Sham, tACS (40 Hz, 1 mA, bilateral prefrontal cortex), or AM-tACS (200 Hz carrier frequency) groups, in AM-tACS, the baseband modulation frequency was individualized based on the pre-task phase-locking value (PLV) derived from occipitofrontal EEG. Working memory (WM) was assessed via a delayed-match-to-sample task (accuracy and sensitivity index d'). Results: Compared to Sham, the tACS group showed significant WM accuracy improvement ( Conclusion: Amplitude-modulated transcranial alternating current stimulation effectively enhances WM in college students, though physiological mechanisms require further investigation with multimodal approaches. The compatibility of AM-tACS with real-time EEG monitoring highlights its potential for closed-loop neuromodulation systems, where stimulation parameters could be dynamically adjusted based on neural feedback.

Indexed as

amplitude modulated transcranial alternating current stimulation (AM-tACS)brain stimulationelectroencephalography (EEG)transcranial alternating current stimulation (tACS)working memory (WM)

Identifiers

PMID41189629
PMCPMC12580318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.