Evidence map›Paper›PMID 41189596›Full record

ArticleiScience2025

Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid.

Pei Fan, Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang, Yiqin Cheng, Chen Li, Yuanyuan Zhang, Pengyu Jia, Yan Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pei FanDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Kui WangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Haidong WeiDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Liufei YangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Shuyue ZhangDepartment of Anesthesiology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yiqin ChengDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Chen LiDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yuanyuan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Pengyu JiaDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yufeng XunCenter for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Yilin WangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Pengbo YangDepartment of Human Anatomy, Histology and Embryology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Pengbo ZhangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Ning WangDepartment of Anesthesiology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine whether sevoflurane causes neurobehavioral abnormality by affecting the microbiota-gut-brain axis, rats were exposed to 3% sevoflurane for 2 h every day on postnatal day (PND) 6, 7, and 8. Sevoflurane exposure in the neonatal period resulted in anxiety-like behavior, social memory damage, and cognitive impairment in adolescent rats. There were significant differences in microflora β diversity between the sevoflurane exposure group and the control group on day 7 and day 21 after exposure. Sevoflurane exposure significantly reduced bacterial species, such as

Indexed as

Developmental biologyMicrobiologyNeuroscience

Identifiers

PMID41189596
PMCPMC12581646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.