Evidence map›Paper›PMID 41189595›Full record

ArticleiScience2025

SLC7A11-specific CAR-T cell therapy potently targets colorectal and pancreatic cancer.

Xiaoxue Pan, Jichang Li, Jing Zhu, Xin Wang, Yucun Liu, Xiaodong Tian, Yinmo Yang, Pengyuan Wang, Shanwen Chen

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoxue PanDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Jichang LiDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Jing ZhuDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Xin WangDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Yucun LiuDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Xiaodong TianDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing 100034, China.
Yinmo YangDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing 100034, China.
Pengyuan WangDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.
Shanwen ChenDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing 100034, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SLC7A11 is highly expressed in various solid tumors, including colorectal cancer and pancreatic cancer. The aim of the study was to report the therapeutic potential of SLC7A11 CAR-T therapy. The SLC7A11-specific antibodies were generated by hybridoma and humanization technologies. The cytotoxicity was validated

Indexed as

CancerImmunologyTherapeutics

Identifiers

PMID41189595
PMCPMC12581705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.