Evidence map›Paper›PMID 41189581›Full record

ArticleERJ open research2025

Extracellular iron and the lung microbiome in smoking and COPD.

Claire Healy, Christina Campbell, Katherine Hoffman, James J Butler, Kristopher Opron, John R Erb-Downward, William Z Zhang, Igor Barjaktarevic, Meilan K Han, Robert J Kaner and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Claire HealySchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Christina CampbellRoyal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0002-8826-9295
Katherine HoffmanDepartment of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
James J ButlerDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA.
Kristopher OpronDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
John R Erb-DownwardDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
William Z ZhangDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA.
Meilan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Robert J KanerDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Christine M FreemanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
R Graham BarrDepartment of Medicine and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Alejandro P ComellasDivision of Pulmonary and Critical Care, University of Iowa, Iowa City, IA, USA.ORCID https://orcid.org/0000-0003-1521-7520
Claire DoerschukUniversity of North Carolina Marsico Lung Institute, Chapel Hill, NC, USA.
Nirupama PutchaJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Wendy MooreWake Forest School of Medicine, Winston-Salem, NC, USA.
J Michael WellsDivision of Pulmonary and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA.
Ruaidhri KeaneRoyal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0001-6655-6130
Sarah O'BeirneDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0003-2876-0258
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6314-0903
Sanjeev RamanDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.
Annette HastieWake Forest School of Medicine, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0001-6607-7797
Robert PaineSection of Pulmonary and Critical Care Medicine, Salt Lake City Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
Nadia N HanselJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Prescott WoodruffUniversity of California, San Francisco, San Francisco, CA, USA.
Russell P BowlerUniversity of Colorado School of Medicine, Aurora, CO, USA.ORCID https://orcid.org/0000-0003-4651-363X
Karla V BallmanDepartment of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, USA.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA.
Yvonne J HuangDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Imran SulaimanRoyal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0003-1992-0280
Suzanne M CloonanSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-5301-9926
SPIROMICS Investigators

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Background: Most microorganisms that make up the lung microbiome use several iron acquisition strategies for survival. Iron levels and iron-associated proteins are higher in the bronchoalveolar lavage fluid (BALF) of smokers with and smokers without COPD associating with disease severity. In this study we assessed whether or not smokers with and smokers without COPD who have increased airway iron display a specifically altered airway microbiome. Methods: 16S ribosomal RNA gene sequencing of BALF from individuals (n=181) enrolled in the bronchoscopy substudy of the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) was paired with measured levels of BALF iron, the iron storage protein ferritin (ex-ferritin) and the host-iron siderophore lipocalin-2 (LCN-2) in matched participants. Results: Overall, iron, ex-ferritin and LCN-2 levels were not associated with ecological diversity metrics in the BALF of participants enrolled in this cohort. However, in a differential analysis, specific taxa were found to be enriched in never-smokers with low BALF ex-ferritin levels and also in smokers with high BALF iron levels. Of participants with COPD, an unclassified taxon, Bacteroidetes Conclusion: The above data suggest that abundance of iron and iron-binding proteins may be linked to the presence of both oral commensals and potentially pathogenic microorganisms in the lower airways of individuals with COPD.

Identifiers

PMID41189581
PMCPMC12581164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.